The growth factors and stromal requirements necessary for effective engraftment are poorly understood and human fibroblasts are rapidly out-competed by mouse stromal cells following transplantation [ 71 ]. Hardcore content is hidden. One possible explanation for elevated take rates in high grade primary tumors could be a higher frequency of tumor-initiating cells TIC a. No competing financial interests Jane Visvader: Mesenchymal stem cells within tumour stroma promote breast cancer metastasis.
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